Scalable Persistent Storage for Erlang

The many core revolution makes scalability a key property. The RELEASE project aims to improve the scalability of Erlang on emergent commodity architectures with 100,000 cores. Such architectures require scalable and available persistent storage on up to 100 hosts. We enumerate the requirements for scalable and available persistent storage, and evaluate four popular Erlang DBMSs against these requirements. This analysis shows that Mnesia and CouchDB are not suitable persistent storage at our target scale, but Dynamo-like NoSQL DataBase Management Systems (DBMSs) such as Cassandra and Riak potentially are. We investigate the current scalability limits of the Riak 1.1.1 NoSQL DBMS in practice on a 100-node cluster. We establish for the first time scientifically the scalability limit of Riak as 60 nodes on the Kalkyl cluster, thereby confirming developer folklore. We show that resources like memory, disk, and network do not limit the scalability of Riak. By instrumenting Erlang/OTP and Riak libraries we identify a specific Riak functionality that limits scalability. We outline how later releases of Riak are refactored to eliminate the scalability bottlenecks. We conclude that Dynamo-style NoSQL DBMSs provide scalable and available persistent storage for Erlang in general, and for our RELEASE target architecture in particular

A Pilot Survey on the Licensing of DNA Inventions

Despite ethical concerns about gene patents, virtually no empirical evidence exists to support claims about either positive or negative effects, and extremely little is known about the intellectual property protection strategies of firms and universities. This article discusses the results of a pilot study to examine patenting and licensing philosophies, policies, and practices of different types of institutions and to describe the contractual conditions for licensing DNA sequence inventions

The Relationship Between Negative Expressivity, Anger, and PTSD Symptom Clusters

More investigation is needed to understand how specific posttraumatic stress disorder (PTSD) symptom clusters relate to the internal experience of anger and overt negative behaviors in response to anger (negative expressivity). We investigated whether anger mediated relations between PTSD symptom clusters and negative expressivity. Multiple regression revealed lower PTSD intrusion symptoms associated with higher levels of negative expressivity. Anger mediated this relationship. Higher avoidance symptoms related to higher negative expressivity. Clinical implications, limitations, and strengths are discussed. (C) 2016 Elsevier Ireland Ltd. All rights reserved

Biowaste to biochar: hydrothermal carbonisation & high temperature torrefaction of food waste anaerobic digestate

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Acceptability of buprenorphine as a treatment for opioid use disorders: Experiences of health providers in Indiana rural counties

Poster presentation at the 2020 American Public Health Association Virtual Annual Meeting and EXPO.This ongoing qualitative study uses medical (72.4%) and non-medical (27.6%) providers’ narratives to explore barriers and facilitators of buprenorphine – an approved Medication Assisted Treatment (MAT). Please note that the poster presentation represents preliminary findings which may change after data collection is completed

Latent Classes of Childhood Poly-victimization and Associations with Suicidal Behavior among Adult Trauma Victims: Moderating Role of Anger

The aims of the present study were first to identify discrete patterns of childhood victimization experiences including crime, child maltreatment, peer/sibling victimization, sexual violence, and witnessing violence among adult trauma victims using latent class analysis; second, to examine the association between class-membership and suicidal behavior, and third to investigate the differential role of dispositional anger on the association between class-membership and suicidal behavior. We hypothesized that those classes with accumulating exposure to different types of childhood victimization (e.g., poly-victimization) would endorse higher suicidal behavior, than the other less severe classes, and those in the most severe class with higher anger trait would have stronger association with suicidal behavior. Respondents were 346 adults (N = 346; Mage = 35.0 years; 55.9% female) who had experienced a lifetime traumatic event. Sixty four percent had experienced poly-victimization (four or more victimization experiences) and 38.8% met the cut-off score for suicidal behavior. Three distinct classes emerged namely, the Least victimization (Class 1), the Predominantly crime and sibling/peer victimization (Class 2), and the Poly-victimization (Class 3) classes. Regression analysis controlling for age and gender indicated that only the main effect of anger was significantly associated with suicidal behavior. The interaction term suggested that those in the Poly-victimization class were higher on suicidal behavior as a result of a stronger association between anger and suicidal behavior in contrast to the association found in Class 2. Clinical implications of findings entail imparting anger management skills to facilitate wellbeing among adult with childhood poly-victimization experiences

Spoxazomicin D and Oxachelin C, Potent Neuroprotective Carboxamides from the Appalachian Coal Fire-Associated Isolate \u3cem\u3eStreptomyces\u3c/em\u3e sp. RM-14- 6

The isolation and structure elucidation of six new bacterial metabolites [spoxazomicin D (2), oxachelins B and C (4, 5), and carboxamides 6–8] and 11 previously reported bacterial metabolites (1, 3, 9–12a, and 14–18) from Streptomyces sp. RM-14-6 is reported. Structures were elucidated on the basis of comprehensive 1D and 2D NMR and mass spectrometry data analysis, along with direct comparison to synthetic standards for 2, 11, and 12a,b. Complete 2D NMR assignments for the known metabolites lenoremycin (9) and lenoremycin sodium salt (10) were also provided for the first time. Comparative analysis also provided the basis for structural revision of several previously reported putative aziridine-containing compounds [exemplified by madurastatins A1, B1, C1 (also known as MBJ-0034), and MBJ-0035] as phenol-dihydrooxazoles. Bioactivity analysis [including antibacterial, antifungal, cancer cell line cytotoxicity, unfolded protein response (UPR) modulation, and EtOH damage neuroprotection] revealed 2 and 5 as potent neuroprotectives and lenoremycin (9) and its sodium salt (10) as potent UPR modulators, highlighting new functions for phenol-oxazolines/salicylates and polyether pharmacophores

Assessing the content validity of the revised Health of the Nation Outcome Scales 65+: the HoNOS Older Adults

Aims and method: Recently, the Health of the Nation Outcome Scales (HoNOS) 65+ was revised. Twenty-five experts from Australia and New Zealand completed an anonymous web-based survey about the content validity of the revised measure, the HoNOS Older Adults (HoNOS OA). Results: All 12 HoNOS OA scales were rated by most (≥75%) experts as ‘important’ or ‘very important’ for determining overall clinical severity among older adults. Ratings of sensitivity to change, comprehensibility and comprehensiveness were more variable, but mostly positive. Experts’ comments provided possible explanations. For example, some experts suggested that additional older adult-specific examples be included in the glossary (e.g., for scales measuring depressed mood, problems with relationships, and problems with activities of daily living). Clinical implications: Experts agreed that the HoNOS OA measures important constructs. Training may be needed to orient experienced raters to the rationale for some revisions. Further psychometric testing of the HoNOS OA is recommended